A release valve is disclosed which in one embodiment includes a housing having a passageway extending therethrough and defining an inlet and an outlet, and a membrane extending across the passageway between the inlet and the outlet. A neuromuscular transmission blocking agent comprising as an active ingredient a highly purified type A botulinum toxin from Clostridium botulinum as infant botulism pathogen and a medicament for treating a disease with a muscle overactivity comprising as an active ingredient said toxin. The heat treatment apparatus 1 estimates temperatures of the wafers W based on outputs of the temperature sensors by using the thermal model and controls the heaters based on the estimated temperatures, applying a heat treatment to the wafers W. Further included is a pump located downstream from the ink distribution assembly, and a sump arranged in fluid communication with the pump for receiving excess ink from the ink distribution assembly. If it is necessary to restart, the hardware and the program can automatically restart the system in the invention.