A model selection process for selecting a finite mixture model that is suitable for a given task is described. The line holding and release device preferably includes two fingers arranged for holding the fishing line, a spring bias means for triggering the release of the line, an alarm circuit, and a spring bias means for activating the alarm circuit. The material has mechanical properties such that, in a first position, in the absence of vertical pressure, it maintains itself erect so that its free end points to outer space, thereby defining an upper face that faces outer space and an opposite lower face that faces the panel, and, in a second position, in response to vertical pressure, it orients its upper face toward the plane of the panel. The puller housing is removably attached to the funnel housing and is also removably attachable to a bronchial flow control device that can be positioned in the loading cavity. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets.