A quadrature modulator divides a part of a transmitted signal to generate a cancel signal. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The detecting of the vulnerable plaque tissue can be accomplished by techniques, such as Magnetic Resonance Imaging, infrared spectroscopy, thermography, blood tests, ultrasound, and X-ray, etc. When a predetermined set of cells visible in the annotated view are subsequently displayed in another view, the annotation may be retrieved via the cell links and an indication of the annotation may be provided. A reference physiological parameter may be compared against a later measurement to identify a change in condition that may indicate a pain management problem.