An output control signal generating circuit includes latch circuits that are connected in cascade, and a timing signal generating circuit that generates a timing signal to be supplied to the latch circuits, based on a second clock of which phase is advanced from the phase of a first clock used to take in a read command. Primary liver cancers, including those metastatic to other parts of the body, as well as cancers metastatic to the liver cancer, can be treated andor prevented with the compositions and methods of the present invention. A portion of the first data packet is then modified, the portion being outside the unenhanced payload of the first data packet, to indicate that a first optimization device is capable of enhanced communication.