A method of fabricating a nano silicon on insulator wafer having an excellent thickness evenness without performing a chemical mechanical polishing and a wafer fabricated by the same are provided. The present invention also relates to the use of specific compositions and methods of manufacture to produce scaffolds that combine biocompatibility with the desired rates of bioabsorption. One or more carrier wheels may be provided between the first and second sets of wheels. For each occurrence of the defined structure, one or more properties of the occurrence of the defined structure may be determined and contained by the corresponding injection data object. The invention also provides methods of identifying inhibitors of tumorigenesis.