The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers. A radio-frequency signal received at a receiving stage is subjected to at least a first filtering step, in which a desired receiving signal is separated from the signal with a filter. The concavities and convexities are provided continuously at a position corresponding to the foot portion or the top portion of the bead of the first metal plate.