The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9\u2032 have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. The lubricating system utilizes flow meters to monitor and control the supply pressure and oil flow to a machine lubrication point. The method also includes: determining the current values for the associated gain, determining the gain margins between the maximum reachable values and the current values, and performing, to optimize the error parameter as a function of the margins, at least one of: varying the number of bits allocated to the tones, and performing a transmitted power variation by varying the gains. In this process, the monitoring device receives the measurement signal, obtains a first pulse profile which is a predicted temporal signal profile of the first pulse, and filters the measurement signal in the time-domain, using the first pulse profile, to essentially eliminate the first pulse while retaining the second pulse. At least one of the discharge port forming member and the flow path forming member is made of a cured material of a composition containing an epoxy resin and a phenol resin having a higher oxygen equivalent than that of the epoxy resin.