A brass wind instrument and method comprising: a single piece body further comprising a plurality of valve cylinders for receiving valves and a plurality of ports and interfaces in fluid communication with said valve cylinder, wherein said ports and interfaces are substantially perpendicular to the axis of said valve cylinder. The invention provides powerful disambiguation processes applied across one or more databases to yield a disambiguated authority database of authors. The outer frame includes a front face having an opening, a back panel spaced from the front face, and side members hingedly connecting the front face and to the back panel. A first platelet activator is sensitive to activation pathway targeted by the anti-platelet drug. In the engaged position, the release member engages the second end portion of the agitator to couple the agitator to the nozzle body within the chamber. Such device has improved controlled for positioning an end of the device at a selected position within the body.