A monitor either usable in cooperation with or apart from a portable cooler to maintain a temperature of medications. These compounds and compositions possess potent activity in treating local and systemic infections, particularly infections caused by sensitive and resistant Gram-positive organism infections, Gram-negative organism infections, mycobacterial infections and nosocomial pathogens, and particularly those belonging to the staphylococcus, streptococcus and enterococcus groups. The method comprises the steps of using a measurement probe to determine the position of the first feature, rotating the first rotatable portion through an angle, and using said measurement probe to determine the new position of the first feature.