There is prepared a printing plate on which a material being hydrophilic at a first temperature and being hydrophobic at a second temperature which is lower than the first temperature is provided. This is accomplished through use of a pair of polymer optical modules, which are used to couple light sent to and received from respective fiber optic cables. Alternatively, mechanical, electro-optical, electrochemical, electrical or other chemical systems may be used to detect the presence of fluid that is leaking near the infusion site. The vertical height of the hinge correlates with the height of the skirt that depends downwardly from the base portion when the height of the skirt is substantially uniform around the perimeter of the container. The tissue specimen is sequentially contacted with components of a reagent system in the presence of increased temperature andor agitation and in the absence of exogenous microwave radiation to facilitate processing in less than one working day.