This invention is directed to methods for treating aneurysms wherein the aneurysmal sac is filled with a non-particulate agent or plurality of such agents andor with a fluid composition which solidifies in situ. The ink refill unit includes a base assembly that has ink refilling components and outlets for engaging a docking member connected to the ink storage compartments. The method is applicable to determining CNV of any fetal aneuploidy, and CNVs known or suspected to be associated with a variety of medical conditions.