A reflection type liquid crystal display device which satisfies at least the performance requirements for high brightness in the bright display and a high contrast. But these methods require a great deal of interferometric control of tip tilt and other motion. Boundaries are also corrected for shifting of photoactive material in photoresists by calculating the amount of shift based on light intensities at pattern points. The request may only be sent when a payment is due. Further, the present invention relates to a method for preparing a transgenic mouse, and a method for monitoring cell or tissue therapy using the transgenic mouse. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.