Test liquid including thermosetting resin is injected from an injection valve. The container has walls of flexible sheet, with at least a second end enclosed with a sheet. Methods of using the compounds for treating PRMT5-mediated disorders are also described. The simulated network is then perturbed by deleting one or more components, changing the concentration of one or more components, or modifying one or more mathematical equations representing the interrelationships between one or more of the components.