A coupler for use in sealing a joint between two pipes. In particular, the methods and apparatuses are used to identify repetitive information in molecules or molecular ensembles, which is interpreted using an autocorrelation function in order to determine structural information about the molecules. By setting the spray speed to about 90 mgmin or more per 1 g of cores when a spray agent for a primary agent containing the biologically active substance is sprayed while spraying a binding liquid to the cores and setting the total feeding weight per unit area for a centrifugal fluidized bed coating granulation machine to about 1. Accordingly, the heat generated by the LED chip can be directly conducted to the liquid-vapor heat-dissipating device and, such that the present invention has preferably thermally conductivedissipating efficiency. The MEMS sensors can be operatively connected to a data acquisition system, which can statistically analyze the emissions values measured by the MEMS sensors.