Methods of \u201creprogramming\u201d epigenetic mark readers or erasers to recognize epigenetic marks other than their cognate marks are provided. The invention utilizes an inner sheathdistal probe end combination to allow atraumatic navigation through the cervical anatomy of the animal to reach the uterus. The method of recording information on the recording layer comprised in the above optical information recording medium by irradiation of a laser beam onto the optical information recording medium.