Improved pharmaceutical compositions are provided comprising one or more solubilized HIV protease inhibiting compounds having improved solubility properties in a medium andor long chain fatty acid, or mixtures thereof, a pharmaceutically acceptable alcohol, and water. The fluid delivery system includes a valve assembly that is triggered by sensing nasal flow. The distribution plate can define a pattern of passages therethrough that further distribute the sublimated source material passing through the distribution manifold. and a number-average molecular weight of from 3,000 to 1,000,000 and ii) an inorganic material.