An accelerated filesystem includes a fast-path and a slow-path. The vacuum pump, a manually operated device, is suitable for creating a vacuum within the container so as to initiate the flow of liquid through a siphoning tube. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. Other embodiments and related methods are further disclosed. Thus, they are potential preventive andor therapeutic agents clinically applicable to various diseases in which human chymase is involved. Thereby, candidate regions are enabled to be extracted while taking into consideration variance in the directions of linear structures.