Pharmaceutical compositions comprising 2-6–3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl-4-fluoro-benzonitrile and pharmaceutically acceptable salts thereof are provided as well as kits and articles of manufacture comprising the pharmaceutical compositions as well as methods of using the pharmaceutical compositions. A payload material may be encapsulated within a wall material. Based on voltages between both ends of the element 5, the control part 8 detects an initial temperature of the steering wheel, further calculates a consumption power required to rise the temperature of the steering wheel up to a set temperature and generate the control signal during a heating period determined on the ground of the consumption power.