A welding device that facilitates depositing of a welding bead on a surface to be built-up. In particular the invention relates to HMG CoA reductase inhibitors and their use in promoting angiogenesis in vivo and in activating Akt in vascular endothelial cells in vitro and in vivo. The papermachine substrate may be made by a process that includes the steps of: providing a paper machine substrate; applying an active agent to the paper machine substrate; and exposing the paper machine substrate to greater than about 2 million rads of radiation to cause a reaction between the active agent and the substrate so the active agent becomes joined to the substrate. The information extracted by the extraction unit is then outputted to the user by an output unit. The virtual machine monitor analyzes an operation performed by the user domain in real time and stores resulting analysis information in the root domain. If the upper bound computed is less than the score of top scoring objects in the results list, then the top scoring objects in the results list may be output.