The present invention provides a pillar of a vehicle body structure for supporting the roof of an automotive vehicle. The second portion of the semiconductor substrate extends adjacent a first side of the first portion of the semiconductor substrate and the third portion of the semiconductor substrate extends adjacent a second side of the first portion of the semiconductor substrate. The front region of the roof includes a rigid assembly disposed under the cover. A flange is formed in the support ring. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.