The invention relates to the novel macrocycles of general formula and to their use in the treatment of tumor diseases. The pressure equalization is effected by opening a pressure equalization passage openingclosing valve incorporated in a pressure equalization passage, after completion of adsorption in a first adsorption tower and after completion of desorption in a second adsorption tower connected to the first adsorption tower via the pressure equalization passage. They are particularly useful as inhibitors of hepatitis C virus NS5B polymerase, as inhibitors of HCV replication, andor for the treatment of hepatitis C infection. By collecting light in a direction in which the viewer is present, light utilization efficiency can be improved.