The present document describes transdermal compositions comprising effective amounts of a nitric oxide amino acid ester compound, a skin penetration enhancer is association with a pharmaceutically acceptable carrier. Preferably the solid active agent is a solid antimicrobial such as zinc pyridinethione. The light emitting surface emits outward the light received through the light incident surface. A third vertical support arm expendably attached to the cap and the second vertical support arm. The cartridge-receiving plate is aligned relative to the base. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.