Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one. A runtime engine receives an identifier of a block of shared memory from a directing process. The jaw members are movable to grasp tissue therebetween. Also included in the apparatus is an actuator control mechanism that is in communication with the actuator. The presence of a mutation in the UMOD supports a diagnosis of a disease or a predisposition to contract a disease within the patient.