The present invention relates to 14- or 15-membered macrolides substituted at the 4\u2033 position of formula and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body. At the time of starting the engine, the control stops the operations of auxiliary machinery, which is driven with the electric power from the battery, until completion of the start of the engine. The optical pointing device further includes a light guiding component installed between the sensing component and the cover. Actuators enable the beam to be placed in a first deformed position, corresponding to a first stable state, or in a second deformed position, corresponding to a second stable state, and the electrical contact ensures connection of the ends of the two conductive tracks.