Toner particles comprise resin, wax and optionally colorants, and the wax is substantially excluded from the interior core of the toner particles. Means are provided to reduce the copy numbers of antibiotic resistance genes, and to confer phage binding to cells lacking receptors for those phage. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The gravity compensation device does not add substantial mass to the basic mass, and is simple in design. Preferably, the indicator uniquely identifies four states regarding the status of computer instruction exchange between the portable and host devices, including normal and inactive, normal and active, error, and ready-to-be-removed states. Combining with the gain-boost-Q technology, it makes the high performance clock chip being comparable to the xtalchip.