A thermal wrap having identical side portions, each having a pocket formed therein for receiving thermal material such as gel packs. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. The systems and methods may be adaptive and grow progressively more accurate as additional user data is received. In another embodiment, the apparatus may include a radiation source that directs impinging radiation toward the microelectronic substrate, exciting atoms of the substrate, which in turn produce an emitted radiation.