A method and system for detecting, locating and quantifying a physical phenomena such as strain or a deformation in a structure. The structures extend at least partially upwards from the surface of a substrate, and may extend fully upward from the substrate surface. In some embodiments, the agents are modulating agents that can modulate a cellular activity or function when introduced into the cell. The grinding spindle unit bears a grinding wheel which is driven in rotation. A flat one-piece postal compliance pre-tool is also disclosed that includes: at least one depression, at least one sticky or adhesive area, at least one mateable hole and insert coupling, or a combination thereof, wherein the flat one-piece postal compliance tool is formed into the postal compliance tools disclosed herein.