The invention relates to antibacterial amide macrocycles and methods for their preparation, their use for the treatment andor prophylaxis of diseases, as well as their use for the production of medicaments for the treatment andor prophylaxis of diseases, in particular of bacterial infections. The problem is formulated as a constrained minimization problem with box, linear equality, and linear inequality constraints. The POS host is operable to configure the host-end wireless communication module for generating a plurality of virtual COM ports. Pins extending radially between the wear caps and supporting bases further enhance the anti-twist resistance between the parts. Application for protecting sensitive data.