A wafer comprises a multi-layer structure. It is well known that an elliptic polynomial discrete logarithm problem is a computationally \u201cdifficult\u201d or \u201chard\u201d problem. One jaw includes a receiver for securing the elongated member to the jaw. The method can include requesting, over the network by the award system unit, exchange of the awards of the first award type in the electronic player account for the awards of the second award type. In particular, the invention provides a sensitive dose response assay for the identification of receptors having alterations in ligand dependent or ligand independent signaling.