1461134863-3288671a-87f8-486b-8408-3131bc5b6158

This invention relates to processes and intermediates for making {1-{1-3-fluoro-2-isonicotinoylpiperidin-4-yl}-3-4–1H-pyrazol-1-ylazetidin-3-yl}acetonitrile, useful in the treatment of diseases related to the activity of Janus kinases including inflammatory disorders, autoimmune disorders, cancer, and other diseases. The fluence is variable by finely controlling the power output of the laser or by changing the spot size of the laser beam. Automatically passing data to an output if the cardinality of the second-tier algorithm is greater than a threshold cardinality, and passing the data back to the second-tier algorithm or to one or a plurality of subsequent algorithms, in response to the cardinality being less than the threshold, and automatically passing the data to an output at the completion of the data processing. A large number of small wheels may be provided on sprung stub-axles.