The present invention, based on the discovery of a new biological phenomena, provides methods and compositions for use in identifying agents that modulate the phosphorylation of survivin, the interaction between survivin and p34cdc2-cyclin B1 kinase complex, and the interaction between survivin and caspase-9. The single cut-off device may include stranded wire, a first solder having a first melting point connecting the stranded wire to the at least one non-linear resistance element, and a second solder having a second melting point, higher than the first melting point, connecting the stranded wire to the at least one non-linear resistance element. Further, the envelope includes adhesive situated on the flap for interacting with the envelope body to maintain the flap at the second configuration. The resetting unit closes the switch at a point in time that the controlled element that is driven by the motor arrives at a specific second opening at a time of restoration of the external power supply in a state wherein the non-linked state of the motor and the controlled element by the button has been undone. The control circuit includes a third register and controls operations of the power source circuit and the sense amplifier.