A food or beverage containing an effective amount of a fructose-6-phosphate-2-kinase inhibitor which is safe and effective in vivo, such as itaconic acid, and a pharmaceutical composition containing the inhibitor as an active ingredient are disclosed. User equipment receives a common reference signal from a first domain having the same cell identity and a channel state information reference signal from a second domain including a configuration of the CSI RS designated by the UE. The pivotal axis of each pivoting arch is eccentric to the axis of rotation of the pedal axle. A flap is defined by an extension of the pouch material and is folded over onto the pouch so as to releasably seal over the exit structure. An encapsulant is formed over the solder bumps. The packaging arrangement includes a modular spool assembly defined by a first flange, an opposing second flange, and a spool hub separating the first flange from the second flange, wherein a telecommunications cable may be wound between the first and second flanges.