A database is queried with on demand database query reduction A query document includes global variables selectively set off by first tags identifying a first global variable as a complete replacement variable and by second tags identifying a second global variable as a complete removal string. In addition, identification data of a second type that belong with a certain probability to the same target individual are automatically determined. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions. In accordance with a particular embodiment, the filter pad may be comprised of at least first and second fibrous mats that are coupled together.