Described herein is a combination therapy suited to the treatment of pancreatic cancer and the like. The system and method for adapting software elements based on application usage may include a knowledge component configured to determine how a user is using an interview-based application including, but not limited to, the functions of the application that the user has utilized, the content that the user has viewed, the tasks that have been performed, and the assistance that has been requested. A clamp reference level of the converted signal is removed prior to applying a digital gain to a digital multiplied. All the circuits merge with one another at the outermost portion.