The present invention relates to indicators of surface preparation and methods of making such indicators. The opening and closing device has a base bracket, a motor, a transmission, a rotary drum, a first conduit fixed portion, a second conduit fixed portion, a first tension controller and a second tension controller. The extrafine metal structures are provided at surfaces thereof with a metal compound part, the metal compound part being formed by performing surface treatment on the surfaces of the extrafine metal structures. For example, an offset in the down level of the gate voltage is created by conditionally developing an offset voltage in the lower rail voltage of the gate driver. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved. The holding portion supports one end of the pressing portion and holds elastically the mounting portion of the base.