A known deepwater solution for production risers for extracting oil and gas is the SLOR\u2122 riser. Advantageously, the disclosed methods and structures permit the use of binary classification technologies to develop better performing, and more scalable Multiple Kernel Learning methods that are conceptually simpler. Also, a method of making the thermistor is described. The shaft also has a cantilever body which wedges into a tapered region in the socket to frictionally bind the shaft and socket together. The dynamic spacer allows for accurately measuring flexion-extension gaps and angular deviation in flexion indicating the appropriateness of femoral rotation. In particular, the invention relates to methods and formulations for treating epithelial wounds based on application of an opioid antagonist such as naltrexone.