A dispenser is provided with a reservoir for a stack of sheets of web material and including a housing. Proposed is constructing a disease-related gene network, mapping medicine-effective genes onto the network, and determining the synergistic effect of medicines on the basis of the genes. The invention also provides methods of manufacturing the multi-layered devices wherein the devices may comprise substrates composed of non-similar materials that are bonded together by anodic bonding. The booster cooling unit is positioned to regulate the temperature of the probe seat of the ultrasonic booster such that the assembly supports a temperature dependent press-fit engagement of the seated end of the ultrasonic probe and the probe seat of the ultrasonic booster. The semiconductor package can include a die mounted in a face-up configuration or in a face-down or flip chip configuration.