The present invention discloses a composition that contains an effective amount of an analgesically andor anti-inflammatory active fraction separated from a mixture of plasma andor serum, and at least one metal, metal ion or metal salt, in which the mixture has been denatured. In certain embodiments, the sleeve or wrap is a protective encasement for protecting a container, such as a bottle. The fluid is more viscous at temperatures lower than the CST as compared to temperatures above the CST. The metal plates are held in bearing engagement on the insulation blocks only by the coupling members.