Novel biphenyl sulfonamide compounds which are combined angiotensin and endothelin receptor antagonists are claimed along with methods of using such compounds in the treatment of conditions such as hypertension and other diseases, as well as pharmaceutical compositions containing such compounds. The transdermal preparation including the film-forming agent of the present invention and active ingredient exhibits excellent elasticity and flexibility, shows superior adhesion power when formed on the skin, and forms non-sticky film. An in-phase signal component and a quadrature-phase signal component can be generated from the carrier signal. By sustaining the phase matching condition over a significant distance, the device is capable of providing terahertz radiation with high peak and average power. A molded reinforcement is fixedly secured to the upper surface of the substrate.