The present invention relates to methods of treating hematological malignancies, including acute myeloid leukemia, comprising the combination of a compound that inhibits the binding of the Smac protein to IAPs and one or more pharmaceutically active agents; pharmaceutical compositions comprising said combination; and a commercial package comprising said combination. The terminal has an intermediate crank-like section formed between its tail and contact section, thereby lowering the contact section toward the tip end of the tail. Sending notification includes sending a special bridge protocol data unit along forwarding links connected to the bridge.