A fluid handling unit 16 has an inside cylindrical portion 16c which is arranged in an outside small-diameter cylindrical portion 16b so as to be eccentric with respect to the outside small-diameter cylindrical portion 16b, and a plurality of slits 16d for establishing a communication between an inside fluid housing chamber 30 and an outside fluid housing chamber 28. The surface of the fifth lens facing the image side is an aspheric surface and includes an inflection point. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders andor conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. If the file is associated with a permission specifying an allowed cumulative playback time of the file, the estimated playback time can be accrued against the allowed cumulative playback time.